abstract：:The cytostatic cytokine tumor necrosis factor-alpha (TNF-alpha) and proliferative hormone adrenomedullin (AM) are abundantly expressed in human tumors. However, little is known about mechanism (s) through which TNF-alpha and AM exert their regulatory effects, especially in the regulation of proliferative activity in m...

journal_title：Neoplasma

authors： Drimal D,Drimal J,Drimal J Jr

更新日期：2006-01-01 00:00:00

abstract：:Although chemoradiotherapy (CRT) is a standard treatment for unresectable locally advanced non-small cell lung cancer (NSCLC), the optimal sequencing remains to be determined. We retrospectively compared the treatment results of induction chemotherapy followed by concurrent CRT (induction group, 32 patients) with thos...

journal_title：Neoplasma

authors： Lee HW,Choi JH,Lim HY,Park JS,Kim HC,Kang S,Oh YT,Chun M,Sheen SS,Oh YJ,Park KJ,Hwang SC

更新日期：2006-01-01 00:00:00

abstract：:Authors evaluated the prevalence of symptoms of the metabolic syndrome and insulin resistance in 25 patients with adrenal incidentalomas (10 men, 15 women) of the mean age 57.9+/-15 years. 15 patients had adrenal adenoma determined by CT or MR scan and 10 had unilateral or bilateral hyperplasia. The prevalence of obes...

journal_title：Neoplasma

authors： Lazúrová I,Dudásová D,Wagnerová H,Dravecká I,Petrásová D

更新日期：2006-01-01 00:00:00

abstract：:The aim of this study was a contemporaneous measurement of plasma cells proliferative and apoptotic activity in patients examined at the time of multiple myeloma (MM) diagnosis before initiation of chemotherapy, focussed on the following aspects: determination of prognostic significance of plasma cell propidium iodide...

journal_title：Neoplasma

authors： Scudla V,Ordeltova M,Minarik J,Dusek L,Zemanova M,Bacovsky J

更新日期：2006-01-01 00:00:00

abstract：:Loss of heterozygosity (LOH) has been shown to be an important prognostic factor in a variety of malignant neoplasm's. Cervical cancer develops as result of multiple genetic alterations. The aim of this study was to analyze presence of LOH in cervical cancer and to identify the correlation between LOH and survival and...

journal_title：Neoplasma

authors： Kozlowski L,Filipowski T,Rucinska M,Pepinski W,Janica J,Skawronska M,Poznanski J,Wojtukiewicz MZ

更新日期：2006-01-01 00:00:00

abstract：:The aim of our work was to develop a fast, reliable and sensitive PCR method to detect K-ras mutations in various clinical samples. There is a need for an unimpeachable method for early diagnosis and/or screening of pancreatic cancer (PC). We optimized and subsequently analyzed four methods based on mutant-enriched PC...

journal_title：Neoplasma

authors： Ugorcáková J,Hlavatý T,Babál P,Janega P,Bukovská G,Halgasová N,Hlavatá A,Timko J,Duris I

更新日期：2006-01-01 00:00:00

abstract：:The aim of the presented study was to evaluate the long-term outcome of breast-conserving surgery and radiation for the treatment of ductal carcinoma in situ (DCIS) and the role of the radiation boost to the tumor bed. The files of 75 women with DCIS treated by breast-conserving surgery followed by definitive radiatio...

journal_title：Neoplasma

authors： Yerushalmi R,Sulkes A,Mishaeli M,Neumann A,Dinerman M,Sulkes J,Rizel S,Yarom N,Gutman H,Fenig E

更新日期：2006-01-01 00:00:00

abstract：:NAT2 as phase II enzyme is involved in the detoxification/activation of various drugs, environmental substances and carcinogenic compounds. A genotyping approach has been used to investigate NAT2 genotype with putative relevance in lung cancer in population of 110 Slovak-Caucasians patients and 167 non-malignant indiv...

journal_title：Neoplasma

authors： Habalová V,Salagovic J,Kalina I,Stubna J

更新日期：2005-01-01 00:00:00

abstract：:In transplanted mice, the P388 tumor grew better in castrated than in non castrated (NC) mice. The proportion of CD8+ in the blood was more numerous in NC mice. The T cell subsets (CD4+ and CD8+) were also high in the mice with small tumor tissue (<10 mg). The correlation observed between the tumor weight and T cell s...

journal_title：Neoplasma

authors： Aboudkhil S,Henry L,Zaid A,Bureau JP

更新日期：2005-01-01 00:00:00

abstract：:The lack of suitable criteria to predict the response to chemo- and or radiotherapy for individual patients with squamous cell carcinoma of the head and neck (HNSCC) remains still a major problem. This study was conducted to analyze prognostic significance of mitotic and apoptotic index and the DNA flow cytometric ana...

journal_title：Neoplasma

authors： Smilek P,Dusek L,Veselý K,Rottenberg J,Kostrica R

更新日期：2005-01-01 00:00:00

abstract：:Modulatory effects of dopamine (DA) on hematotoxicity and antitumor efficacy of cyclophosphamide (CY) were studied in Swiss mice bearing transplantable Ehrlich ascites carcinoma (EAC). DA was administered i.p. at a dose of 50 mg/kg/day for 5 consecutive days beginning day 3 after tumor transplantation. CY (200 mg/kg i...

journal_title：Neoplasma

authors： Lakshmi C,Deb C,Ray C,Ray MR

更新日期：2005-01-01 00:00:00

abstract：:The aim of the study was to evaluate the influence of the receptor status of primary breast cancer and of a number of selected clinical and morphological patient characteristics. The receptors were determined by biochemical radiocompetitive methods. Disease free survival (DFS) and overall survival (OS) were determined...

journal_title：Neoplasma

authors： Skasko E,Paszko Z,Mazur S

更新日期：2005-01-01 00:00:00

abstract：:A 65-kDa tumor-associated protein (P65) is a potential non- specific tumor marker expressed by many types of tumor cells. Our recent studies indicate that P65 gene expression is connected with poor prognosis for the patients with colorectal cancer. In the present study P65 gene expression was determined by means of RT...

journal_title：Neoplasma

authors： Balcerczak E,Jankowski T,Becht A,Balcerczak M,Janiuk R,Jesionek-Kupnicka D,Sztompka J,Mirowski M

更新日期：2005-01-01 00:00:00

abstract：:The main problem in total body irradiation (TBI) is obtaining a homogenous dose distribution inside the whole irradiated body and ensuring appropriate dose reduction in the lungs. The process of irradiation should be comfortable for the patients and repeatable despite the size and age diversity among patients. The aim...

journal_title：Neoplasma

authors： Malicki J,Skrobala A,Kosicka G,Wachowiak J

更新日期：2005-01-01 00:00:00

abstract：:Monitoring of BCR-ABL transcript level is widely used in chronic myeloid leukemia (CML) to follow up response to therapy. In this study we compare abilities of two quantitative RT-PCR assays to characterize the disease status in CML patients: RT-PCR quantifying the BCR-ABL transcript concentration and RT-PCR determini...

journal_title：Neoplasma

authors： Moravcova J,Regner J,Mouckova D,Fiser K,Zmekova V,Malacova R,Michalova K,Klamova H

更新日期：2005-01-01 00:00:00

abstract：:We analyzed 30 peripheral blood stem cell transplantations (PBSCT) from 25 human leukocyte antigen (HLA) matched sibling donors (MSD) and 4 HLA-matched unrelated donors (MUD) in 29 patients, done between November 1996 and March 2003. Patients aged 3 to 17 years underwent allogeneic PBSCT for malignant (16 patients) an...

journal_title：Neoplasma

authors： Sufliarska S,Horáková J,Bodová I,Martinka J,Hrubisko M,Kovács L,Jancovicová K,Lukác J

更新日期：2004-01-01 00:00:00

abstract：:Prolonged lifespan of monoclonal lymphocytes in B-cell lymphocytic leukemia (B-CLL) arises from their resistance to programmed cell death. In contrast, when cultured in vitro, B-CLL tumour cells rapidly undergo apoptosis. There is mounting evidence that P-glycoprotein (P-gp), an adenosine triphosphate-binding cassette...

journal_title：Neoplasma

authors： Jamroziak K,Smolewski P,Cebula B,Szmigielska-Kaplon A,Darzynkiewicz Z,Robak T

更新日期：2004-01-01 00:00:00

abstract：:We examined the effect of gamma-irradiation (4 Gy) alone or combined with estrogen (17beta-estradiol 15 microM) treatment on the radiation response of stromal fibroblasts from cervical tumors. The fibroblasts were derived from tumors of 9 younger (<50 years) and 9 older (>50 years) cervical cancer patients. A normal f...

journal_title：Neoplasma

authors： Gasinska A,Adamczyk A,Kojs Z,Szumiel I

更新日期：2004-01-01 00:00:00

abstract：:Aim of the study was to compare the fine needle aspiration cytology findings of benign breast lesions with incidence of proliferation markers and apoptosis. This study included 37 patients with palpable breast lumps, referred for USG guided FNA. FNAC were prospectively classified as C2-benign, C4-suspicious of maligna...

journal_title：Neoplasma

authors： Swiatecka J,Laudański P,Dziecioł J

更新日期：2004-01-01 00:00:00

abstract：:Stage I rectal cancer (T1N0M0, T2N0M0) carries excellent prognosis with up to 90% of long term survival rates and complete cure can be expected with curative surgery. However 10 to 15% of these patients show local recurrence and mortality seen in five years. The aim of this study is to analyze the prognostic factors t...

journal_title：Neoplasma

authors： Celen O,Yildirim E,Berberoglu U

更新日期：2004-01-01 00:00:00

abstract：:The study was aimed at the proper detection of surface and cytoplasmic clonal Ig light/heavy chains in the frame of multiparameter flow cytometry analysis of some B-cell malignancies. An exact direct evidence has been obtained that the leukemia cells following staining by antibodies to immunoglobulins will need to be ...

journal_title：Neoplasma

authors： Babusíková O,Stevulová L

更新日期：2004-01-01 00:00:00

abstract：:Currently, mechanisms leading to both apoptosis induction and the development of hormone-independence of prostate carcinoma cells are intensively studied. Attention is also given to the possibility of restoring cell sensitivity to hormone-antagonists. The present study focuses on the effect of the combined synthetic c...

journal_title：Neoplasma

authors： Knillová J,Bouchal J,Hlobilková A,Strnad M,Kolár Z

更新日期：2004-01-01 00:00:00

abstract：:The ultrasonic diagnosis of salivary gland diseases can give a more accurate information than clinical data alone. In diagnosis of the parotid gland diseases, it is necessary to differentiate clearly tumors from other diseases. When a tumor is suspected, its presence should be confirmed, and determined if it is solita...

journal_title：Neoplasma

authors： Ivanová S,Slobodníková J,Janská E,Jozefáková J

更新日期：2003-01-01 00:00:00

abstract：:The results from our investigations concerning the secretory activity of interleukin 10 (IL-10) by two transplantable melanoma cells showed that a spontaneous alteration of the native-melanotic line into an amelanotic form and the tumor progression connected with it, were accompanied by a 6-fold decrease of the IL-10 ...

journal_title：Neoplasma

authors： Kozłowska K,Zarzeczna M,Cichorek M,Wójcik S

更新日期：2003-01-01 00:00:00

abstract：:The aim of this study was a contemporaneous measurement and a mutual comparison of plasma cells proliferative activity and grade of apoptosis in patients with monoclonal gammopathy of undetermined significance (MGUS) and various phases of MM i.e. smoldering (SMM), stable/plateau and active (progression/relapse) forms ...

journal_title：Neoplasma

authors： Scudla V,Ordeltova M,Bacovsky J,Vytrasova M,Sumna E,Martinek A,Horak P

更新日期：2003-01-01 00:00:00

abstract：:Occurrence of uveal metastases is higher, than the number of clinically diagnosed cases, furthermore all cases are not amenable to therapy. Treatment of primary cancer is permanently improving, as a result life prospective is better, with an increasing number of late distant metastases in an unusual location, as e.g. ...

journal_title：Neoplasma

authors： Bajcsay A,Kontra G,Récsán Z,Tóth J,Fodor J

更新日期：2003-01-01 00:00:00

abstract：:Germline mutations in the BRCA1 and BRCA2 genes are required for the initiation of the development of hereditary forms of breast and ovarian cancer, which represent 10-15% of all cases. The course of the disease varies from case to case that can be due even to the possibility of multiple genetic changes including inac...

journal_title：Neoplasma

authors： Cierniková S,Tomka M,Sedláková O,Reinerová M,Stevurková V,Kovác M,Cente M,Ilenciková D,Bella V,Zajac V

更新日期：2003-01-01 00:00:00

abstract：:The objective of the present study was to evaluate clinical condition and results of surgical treatment of patients with typical and atypical bronchial carcinoids. The study was based on retrospective analysis of a total of 96 patients (mean age 47.3 year, age range 21-76, 44 men and women 52), who were surgically tre...

journal_title：Neoplasma

authors： Fiala P,Petrásková K,Cernohorský S,Kinkor Z,Krepela E,Zatloukal P

更新日期：2003-01-01 00:00:00

abstract：:The anti-tumor effects of i.p. administered cyclooxygenase inhibitor - diclofenac and i.v. administered liposomal muramyl tripeptide phosphatidylethanolamine (MTP-PE) were investigated using a s.c. growing murine fibrosarcoma tumor. Tumor growth was assessed by measuring tumor volumes and survival of the mice. Both of...

journal_title：Neoplasma

authors： Fedorocko P,Hoferová Z,Hofer M,Brezáni P

更新日期：2003-01-01 00:00:00

abstract：:Progressive ascitic growth of a spontaneous transplantable T-cell lymphoma, designated as Dalton's lymphoma (DL), in a murine host has been shown to be associated with an involution of thymus accompanied by a massive depletion of the cortical region and an alteration in the distribution of thymocytes by a decrease of ...

journal_title：Neoplasma

authors： Shanker A,Singh SM

更新日期：2003-01-01 00:00:00

abstract：:Hemostatic disorders mainly due to thrombocytopenia represent an important clinical problem in patients with myelodysplastic syndromes (MDS). Much less is known about the possible coagulation abnormalities. Thirty patients with MDS were studied. Activity of cancer procoagulant (CP), concentrations of activation marker...

journal_title：Neoplasma

authors： Chojnowski K,Treliński J,Wawrzyniak E,Sobolewska M,Mielicki W

更新日期：2002-01-01 00:00:00

abstract：:Multiple primary tumors are not rare: they are encountered in 3-5% of malignant tumors. They are particularly frequent in the head and neck [20]. They are most often met with secondary malignant tumors; triple tumors occur in only 0.5%, quadruple tumors in 0.3% of malignant tumors. The possibility of developing a seco...

journal_title：Neoplasma

authors： Németh Z,Czigner J,Iván L,Ujpál M,Barabás J,Szabó G

更新日期：2002-01-01 00:00:00

abstract：:The isoquinoline peripheral benzodiazepine receptor ligand PK11195 increased drug (daunomycin)- and fluorochrome (calcein-AM) uptake and induced apoptosis detected by flow cytometry (FCM) technique, DNA electrophoretic analysis and poly(ADP-ribose) polymerase (PARP) cleavage in human multidrug-resistant myeloid leukem...

journal_title：Neoplasma

authors： Jakubikova J,Duraj J,Hunakova L,Chorvath B,Sedlak J

更新日期：2002-01-01 00:00:00

abstract：:The growth of solid tumors and their metastasis is dependent on the development of new blood vessels (angiogenesis). In our previous studies it was found that angiogenesis inhibitor TNP-470 acting systematically can decrease the rate of growth of transplantable Bomirski Abmelanoma in hamsters. In this study we applied...

journal_title：Neoplasma

authors： Myśliwski A,Koszałka P,Bigda J,Szmit E

更新日期：2002-01-01 00:00:00

abstract：:Analysis of new primary tumors following nonmelanoma skin cancers (NMSC) has a public health and risk assessment interest, as well as potential implications for etiologic inference. The aim of this study is to evaluate the risk of the second primary tumors occurrence after NMSC development. A cohort of 2620 cases (133...

journal_title：Neoplasma

authors： Troyanova P,Danon S,Ivanova T

更新日期：2002-01-01 00:00:00

abstract：:The short-term (7 days) effect of tamoxifen on apoptosis and mitosis index, p53, Bcl2 and Her-2/neu/c-erb2 expression in invasive ductal mammary carcinoma was studied histologically in the diagnostic biopsy and surgically removed tumor tissue of 10 patients. Following tamoxifen treatment expression of HER-2 and p53 de...

journal_title：Neoplasma

authors： Farczádi E,Kaszás I,Baki M,Szende B

更新日期：2002-01-01 00:00:00

abstract：:The aim of this study was to evaluate the clinical and pathological features of breast cancer patients with bilateral breast cancer and to assess the impact of the second breast cancer on their prognosis. Thirty six breast cancer patients with bilateral (metasynchronous) cancer were treated in Greatpoland Cancer Cente...

journal_title：Neoplasma

authors： Skowronek J,Piotrowski T

更新日期：2002-01-01 00:00:00

abstract：:Resistance to chemotherapy significantly affects the treatment results in various cancers. Multidrug resistance caused by P-glycoprotein expression is now widely studied in human malignancies. We present the results of P-glycoprotein expression examination in 91 tumor tissue samples obtained from children treated for ...

journal_title：Neoplasma

authors： Kucerová H,Sumerauer D,Drahokoupilová E,Pisková M,Bedrnícek J,Eckschlager T

更新日期：2001-01-01 00:00:00

abstract：:This study was undertaken to examine the influence of etoposide and doxorubicin on the distribution of vimentin in cells of human leukemia cell line K-562 by using immunofluorescence microscopy. The cells were cultured with 5 different doses of etoposide: 0.02, 0.2, 2, 20, 200 microM/l and three doses of doxorubicin: ...

journal_title：Neoplasma

authors： Grzanka A

更新日期：2001-01-01 00:00:00

abstract：:Our objective was to compare different methods for studying programmed cell death in adherent H460 non-small lung cancer cells of moderate clonogenic radiosensitivity. The major effect of gamma-radiation was found to be the release of cells from the substratum. The different methods gave complementary and unexpected i...

journal_title：Neoplasma

authors： Broquet P,Rodriguez-Lafrasse C,Alphonse G,Aloy MT,Louisot P,Rousson R

更新日期：2001-01-01 00:00:00